Uptake and intracellular activity of ketolide HMR 3647 in human phagocytic and non-phagocytic cells
نویسندگان
چکیده
منابع مشابه
Ketolide agents HMR 3004 and HMR 3647 (telithromycin) inhibit the growth of Plasmodium falciparum in vitro.
BACKGROUND Malaria is on the increase due to emergence of parasite drug resistance and there is thus an urgent need for the development of new antiparasitic drugs effective at low concentrations. Ketolides antibiotics are used for treatment of various ailments and are relevant candidates to establish antiparasitic activity. OBJECTIVES The present study investigates the activity of ketolide co...
متن کاملBronchopulmonary disposition of the ketolide telithromycin (HMR 3647).
Telithromycin (HMR 3647) is the first member of a new family of antimicrobials, the ketolides, developed specifically for the treatment of community-acquired respiratory tract infections. Telithromycin has proven in vitro activity against both common and atypical respiratory tract pathogens. The penetration of telithromycin into bronchopulmonary tissues and subsequent elimination from these sit...
متن کاملIn vitro activity of a new ketolide antibiotic, HMR 3647, against Chlamydia pneumoniae.
The in vitro activities of HMR 3647, roxithromycin, erythromycin, and azithromycin against 19 strains of Chlamydia pneumoniae were tested. The MIC at which 90% of the isolates are inhibited and the minimum bactericidal concentration at which 90% of the isolates are killed of HMR 3647 were 0.25 microgram/ml (range, 0.015 to 2 micrograms/ml). Nine recently obtained clinical isolates from children...
متن کاملThe in-vitro activity of HMR 3647, a new ketolide antimicrobial agent.
The in-vitro activity of HMR 3647, a novel ketolide, was investigated in comparison with those of erythromycin A, roxithromycin, clarithromycin (14-membered ring macrolides), amoxycillin-clavulanate and ciprofloxacin against 719 recent clinical Gram-positive, Gram-negative and anaerobic isolates and type cultures. HMR 3647 generally demonstrated greater activity than the other compounds with MI...
متن کاملInteractions between HMR 3647, a new ketolide, and human polymorphonuclear neutrophils.
HMR 3647, a new ketolide, is active upon intracellular pathogens. We previously demonstrated that HMR 3004 (RU 64004), another ketolide, is highly concentrated by human polymorphonuclear neutrophils (PMNs). This prompted us to evaluate whether the presence of a 3-keto group instead of an L-cladinose, a neutral sugar characteristic of erythromycin A derivatives, confers peculiar pharmacokinetic ...
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ژورنال
عنوان ژورنال: Clinical Microbiology and Infection
سال: 2001
ISSN: 1198-743X
DOI: 10.1046/j.1469-0691.2001.00213.x